Two adventurous women in love are desperate to have their own biological child. They take a chance on an experimental scientific process and make sperm from their own stem cells. Pregnant with humor and unexpected twists, their journey ultimately confirms that all life is a gift and all families are crazy.

High-powered fashion photographer Claire Jameson finds herself stranded in middle America on the way to her dream Christmas-time wedding in Aspen. Unable to get another flight or rent a car, Claire is reduced to begging for a ride. When the rugged former artist turned teacher, Tom Pullman and his 13-year old daughter Hilly kindly offer to take her, none of them realize that their journey is just beginning, and it will leave all of them in a very different place than where they began.

It's 18:00 in a somewhat deserted Toronto on the last day before the scheduled end of the world at midnight, the end which has been known now for months. Most people are treating midnight as a matter-of-fact event with little sense of panic. In fact, many are celebrating this last day. Most have very specific wants for this last day and will do whatever they need to to make those wants happen. And some, such as Duncan and Donna with the gas company, are working, ensuring that the masses are served and comfortable during the final hours. The Wheeler family are marking the last day by having a Christmas party, although sullen adult son Patrick, his thoughts in part stemming from being recently widowed, has made it clear he wants to be alone in his own home at the end. Patrick's wants may be in jeopardy when a woman named Sandra - Duncan's wife - lands on his doorstep. Sandra is stranded, trying...

The movie will shift its focus on Erik Stifler, the cousin of Matt and Steve, a youngster who is nothing like his wild relations. Peer pressure starts to turn him to live up to the legacy of the other Stiflers when he attends the Naked Mile, a naked run across the college campus. Things get worse when he finds that his cousin Dwight is the life of the party down at the campus.